CAS NO: | 112901-68-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potenthypoxia-inducible factor-α1 (HIF-α1)andp53inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4]. | ||||||||
体外研究 (In Vitro) | Amifostine (0.78125-100 μM, 24 h) trihydrate reduces tert-Butyl hydroperoxide (TBHP)-induced cell damage in a dose-dependent manner and significantly reduces H9c2 cells apoptosis at a concentration of 100 μM[5]. | ||||||||
体内研究 (In Vivo) | Amifostine (i.v., 400 mg/kg, 4 h) trihydrate has a protective effect against myocardial I/R injury in male C57BL/6 mice[5].
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Clinical Trial | |||||||||
分子量 | 284.27 | ||||||||
Formula | C5H21N2O7PS | ||||||||
CAS 号 | 112901-68-5 | ||||||||
中文名称 | 氨磷汀三水合物;安磷汀三水合物;阿米福汀三水合物 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |