CAS NO: | 1622849-58-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | GSK481 is a highly potent, selective, and specificreceptor interacting protein 1 (RIP1) kinaseinhibitor with anIC50of 1.3 nM, which inhibits Ser166phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with anIC50of 10 nM[1]. | ||||||||||||||||
IC50& Target | IC50: 1.3 nM (RIP1), 2.8 nM (Ser166phosphorylation in wild-type human RIP1)[1] | ||||||||||||||||
体外研究 (In Vitro) | GSK481 (300 nM; 2 hours; Jurkat cells) abrogates the RIP3 up-regulation induces by both TNFa and shikonin in live and dead cells, indicating that necroptosis is in fact induced by both agents[2]. Apoptosis Analysis[2]
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体内研究 (In Vivo) | GSK481 inhibits Ser166phosphorylation in three mouse RIP1 mutants (IC50=18~110 nM) more potently than in wild-type mouse[1]. | ||||||||||||||||
分子量 | 377.39 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H19N3O4 | ||||||||||||||||
CAS 号 | 1622849-58-4 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 35 mg/mL(92.74 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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