CAS NO: | 1579965-12-0 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | GSK2983559 free acid (compound 3) is an orally active and potentreceptor interacting protein 2(RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells[2]. Cell Viability Assay[2]
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体内研究 (In Vivo) | GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse[2].
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Clinical Trial | |||||||||||||||||
分子量 | 538.53 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H23N4O7PS2 | ||||||||||||||||
CAS 号 | 1579965-12-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 5 mg/mL(9.28 mM;ultrasonic and warming and heat to 80℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |