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ONX 0801 trisodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ONX 0801 trisodium图片
CAS NO:1097638-00-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
BGC 945 trisodium
Idetrexed trisodium
CB 300945 trisodium
产品介绍
ONX 0801 (BGC 945) trisodium 是胸腺激酶合成酶(TS)的抑制剂,靶向α 叶酸受体过表达的肿瘤。
生物活性

ONX 0801 (BGC 945) trisodium is athymidylate synthase(TS)inhibitor, targeted to α-folate receptor–overexpressing tumors[1][2].

体外研究
(In Vitro)

ONX 0801 (BGC 945) is designed to further reduce toxicity by more effectively targeting cancer cells that overexpress the α-FR[1].
ONX 0801 (BGC 945) exhibits IC50values of of 6.6 μM, 1.1 nM, 3.3 nM, 90 nM and 0.32 μM in A431, A431-FBP, KB, IGROV-1 and JEG-3 cells[2].

体内研究
(In Vivo)

BGC 945 (100 mg/kg, ip/iv injection) in the tumor had a longer half-life (28 hours) compared with other tissues[2].
BGC 945 (100 mg/kg daily for 16 days) does not lead to body weight loss, macroscopic signs of toxicity to the major organs, or a change in renal function[2].
BGC 945 at 100mg/kg induces a 5-20-fold increase in tumor dUrd at 4-72h without increases in the plasma, consistent with tumor targeting[2].

Animal Model:Mice (on the folate-free diet for 5 days were transplanted with tumor and the implants)[2].
Dosage:100 mg/kg (Pharmacokinetic Analysis).
Administration:Single i.p. or iv injection.
Result:After i.p. injection, the compound was well absorbed from the peritoneal cavity. The plasma AUC was 50% higher for i.p. compared with i.v. administration and was also higher in spleen, kidney, and liver by this route. Tumor AUC was similar via either route.
Clinical Trial
分子量

713.58

Formula

C32H30N5Na3O10

CAS 号

1097638-00-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.