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Kdo2-Lipid A ammonium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kdo2-Lipid A ammonium图片
CAS NO:1246298-62-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Kdo2-Lipid A ammonium 是一种化学定义的脂多糖 (LPS) ,其内毒素活性等同于 LPS。Kdo2-Lipid A ammonium 对TLR4具有高度选择性。Kdo2-Lipid A ammonium 刺激TNFPGE2的释放。
生物活性

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective forTLR4. Kdo2-Lipid A ammonium stimulates the release of bothTNFandPGE2[1].

IC50& Target

TLR4

 

体外研究
(In Vitro)

Kdo2-Lipid A (1 μM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures[1].

RT-PCR[1]

Cell Line:TNF and PGE2
Concentration:1 μM
Incubation Time:
Result:Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.
体内研究
(In Vivo)

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats[1].

Animal Model:Rats (Male Holzman Sprague-Dawley, 300–400 g)[1]
Dosage:0.1 to 10 μg
Administration:I.T.; 0.1-10 μg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result:Intrathecal injection of 1 μg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.
Clinical Trial
分子量

2306.84

性状

Solid

Formula

C110H214N6O39P2

CAS 号

1246298-62-3

结构分类
  • Others
来源

E. coli

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)