Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selectiveproteasomeinhibitor, and potently inhibits20Sproteasome(K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, inducesapoptosis, and inhibitsNF-κB. Bortezomib is the firstproteasome inhibitoranticancer agent. Anti-cancer activity^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

392.29

Solid

C₁₉H₁₇D₈BN₄O₄

硼替佐米 d8

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)