Aplyronine A

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Aplyronine A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

151923-84-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Aplyronine A 是一种特异性肌动蛋白解聚剂。 Aplyronine A 具有抗肿瘤和凋亡作用。 Aplyronine A 可用于癌症、肌肉收缩、细胞运动和细胞分裂的研究。

生物活性

Aplyronine A is a specificactin-depolymerizingagent. Aplyronine A has antitumor andapoptosiseffect. Aplyronine A can be used for the research ofcancerand muscle contraction, cell motility and cell division^[1].

IC₅₀& Target

IC50: 0.01 nM (HeLa S3 cells)^[1].
EC50: 1.3 μM (F-actin)^[1]

体外研究
(In Vitro)

Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with an IC₅₀value of 0.01 nM^[1].
Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC₅₀value of 1.3 μM in vitro actin-depolymerizing assay^[1].
Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells^[1].
Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis^[1].

Western Blot Analysis^[1]

Cell Line:	HeLa S3 cells
Concentration:	0-1 μM
Incubation Time:	0-2 h
Result:	Induced the dephosphorylation of FAK in HeLa S3 cells.

Apoptosis Analysis^[1]

Cell Line:	HeLa S3 cells
Concentration:	100 nM
Incubation Time:	24 h
Result:	Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells.

体内研究
(In Vivo)

Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells^[1].

分子量

1076.44

Formula

C₅₉H₁₀₁N₃O₁₄

CAS 号

151923-84-1

结构分类

Alkaloids
Other Alkaloids

Others

来源

Aplysia kurodai

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.