Folinic acid (Leucovorin) calcium hydrate is a biological folic acid and is generally administered along withMethotrexate (MTX)(HY-14519) as a rescue agent to decrease MTX-induced toxicity^[1].

Methotrexate (MTX) alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid calcium hydrate at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid calcium hydrate (12 to 54% for MNBN and 20 to 61% for Abs)^[1].

Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) calcium hydrate treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)^[2].

531.53

C₂₀H₂₅CaN₇O₈

1097832-14-8

亚叶酸钙水合物

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.