CAS NO: | 1096702-14-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-drug conjugate (SMDC)[2]. |
IC50& Target | Folate receptor[1] |
体外研究 (In Vitro) | The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50)[1]. FR-positive KB cells are highly sensitive to EC0489 with an IC50of 5 nM[1]. |
体内研究 (In Vivo) | EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner[1]. |
分子量 | 2550.68 |
Formula | C111H156N22O43S2 |
CAS 号 | 1096702-14-5 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |