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EC0489
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1096702-14-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
EC0489是叶酸和去乙酰长春碱酰肼的偶联物,是叶酸受体 (FR)的高亲和力配体。可用于难治性或转移性肿瘤的研究。 是一种小分子-药物偶联物 (SMDC)。
生物活性

EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-drug conjugate (SMDC)[2].

IC50& Target

Folate receptor[1]

体外研究
(In Vitro)

The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50)[1].

FR-positive KB cells are highly sensitive to EC0489 with an IC50of 5 nM[1].

体内研究
(In Vivo)

EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner[1].

分子量

2550.68

Formula

C111H156N22O43S2

CAS 号

1096702-14-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.