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ATM Inhibitor-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ATM Inhibitor-1图片
CAS NO:2135639-94-8
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ATM Inhibitor-1 是一种有效、选择性、可口服的ATM抑制剂，IC50值为 0.7 nM，对 mTOR (IC50，21 μM)，DNAPK (IC50，2.8 μM)，PI3Kα (IC50，3.8 μM)，PI3Kβ (IC50，10.3 μM)，PI3Kγ (IC50，3 μM) 和 PI3Kδ (IC50，0.73 μM) 的作用很弱。ATM Inhibitor-1 具有抗肿瘤活性。
生物活性

ATMInhibitor-1 is a highly potent, selective and orally activeATMinhibitor, with anIC50of 0.7 nM, shows weak activity againstmTOR(IC50, 21 μM), DNAPK (IC50, 2.8 μM),PI3Kα(IC50, 3.8 μM),PI3Kβ(IC50, 10.3 μM),PI3Kγ(IC50, 3 μM) andPI3Kδ(IC50, 0.73 μM).ATMInhibitor-1 exhibits anti-tumor activity[1].

IC50& Target[1]

ATM

0.7 nM (IC50)

ATM

2.8 nM (IC50, Cellular assay)

mTOR

21 μM (IC50)

DNAPK

2.8 μM (IC50)

PI3Kα

3.8 μM (IC50)

PI3Kβ

10.3 μM (IC50)

PI3Kγ

3 μM (IC50)

PI3Kδ

0.73 μM (IC50)

体外研究
(In Vitro)

ATM Inhibitor-1 (Compound 21) is a highly potent, selective and orally active ATM Inhibitor, with an IC50of 0.7 nM, shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM)[1].
In cellular assays, ATM Inhibitor-1 exhibits IC50s of 2.8 nM, >30 μM and >19 μM for ATM, ATR/PI3Kα and PI3Kβ/mTOR, respectively[1].

体内研究
(In Vivo)

ATM Inhibitor-1 (Compound 21; 50 mg/kg p.o. once daily for 3 days every week starting 24 h post-irinotecan dosing, 21 days) in combination with 50 mg/kg irinotecan significantly reduces tumor growth in SW620 mice model[1].

Animal Model:SW620 mice model[1]
Dosage:50 mg/kg
Administration:P.O., once daily for 3 days every week starting 24 h post-irinotecan dosing, 21 days
Result:Inhibited the growth of tumor combined with 50 mg/kg irinotecan in SW620 mice model.
分子量

492.61

Formula

C27H36N6O3

CAS 号

2135639-94-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.