您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Derrone
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Derrone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Derrone图片
CAS NO:76166-59-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Derrone 是一种戊烯基异黄酮,是Aurora激酶抑制剂,其对Aurora BAurora AIC50值分别为 6 和 22.3 μM。Derrone 显示出抗肿瘤活性。
生物活性

Derrone, a prenylatedisoflavones, is anAurora kinaseinhibitor, withIC50values of 6 and 22.3 μM againstAurora BandAurora A, respectively. Derrone shows anti-tumor activity[1][2].

IC50& Target

IC50: 6 μM (Aurora kinase B), 22.3 μM (Aurora kinase A)[1]

体外研究
(In Vitro)

Derrone (30-60 μM, 15 days) significantly inhibits the formation and growth of MCF7 tumor spheroids, with the tumor spheroid growth inhibition (% TGI) of 17.5% and 65.4% for 30 and 60 μM Derrone, respectively[1].
Derrone shows the autophagic features, such as the conversion of LC3-I to LC3-II, the formation of autophagosome and the downregulation of SQSTM1/p62 (p62)[2].
Derrone induces autophagic cell death through intracellular ROS and sustained ERK phosphorylation in A549 cells[2].

分子量

336.34

Formula

C20H16O5

CAS 号

76166-59-1

结构分类
  • Flavonoids
  • Isoflavones
  • Phenols
  • Monophenols
来源
  • Plants
  • Moraceae
  • Maclura pomifera (Raf.) Schneid.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.