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Aurora Kinases-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aurora Kinases-IN-2图片
CAS NO:2241914-86-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Aurora Kinases-IN-2 (compound 12Aj) 是一种有效的 Aurora 激酶抑制剂 (Aurora kinases),对 Aurora A 和 Aurora B 的IC50值分别为 90 和 152 nM。Aurora Kinases-IN-2 通过调节细胞周期蛋白 B1 和 cdc2 将细胞周期阻滞在 G2/M 期。Aurora Kinases-IN-2 可用于癌症研究。
生物活性

Aurora Kinases-IN-2 (compound 12Aj) is a potentAurora kinasesinhibitor withIC50values of 90 and 152 nM forAurora AandAurora B. Aurora Kinases-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora Kinases-IN-2 can be used forcancerresearch[1].

IC50& Target[1]

Aurora A

90 nM (IC50)

Aurora B

152 nM (IC50)

体外研究
(In Vitro)

Aurora Kinases-IN-2 (compound 12Aj) (72 hours) has antiproliferative activity with IC50values of 11.5 μM, 1.34 μM, 7.30 μM and 1.64 μM for U87, HeLa, HepG2 and LoVo tumor cell lines, respectively[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) inhibits Aurora A and Aurora B in HeLa cells[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours; HeLa cells) results in G2/M accumulation by regulating the expression of Cyclin B1 and cdc2[1].
Aurora Kinases-IN-2 (compound 12Aj) (0-10 μM; 24 hours) blocks phosphorylation of Aurora kinases in HeLa cells[1].

Western Blot Analysis[1]

Cell Line:HeLa cells
Concentration:0, 1, 5 and 10 μM
Incubation Time:24 hours
Result:Decreased the expression level of Aurora A and B, as well as reduced phosphorylation of Aurora A on Thr288 (p-Thr288) and Aurora B on Thr232 (p-Thr232) in a dose-dependent manner.
分子量

435.86

Formula

C22H18ClN5O3

CAS 号

2241914-86-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.