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Hesperadin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hesperadin hydrochloride图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Hesperadin hydrochloride 是Aurora AB的 ATP 竞争性吲哚酮抑制剂。Hesperadin hydrochloride 以 250 nM 的IC50抑制 Aurora B。
生物活性

Hesperadin hydrochloride is an ATP competitive indolinone inhibitor ofAurora AandB. Hesperadin hydrochloride inhibitsAurora Bwith anIC50of 250 nM[1].

IC50& Target[1]

Aurora B

250 nM (IC50)

体外研究
(In Vitro)

Hesperadin (10-100 nM) inhibits the Aurora kinase-1 (TbAUK1)-mediated phosphoryation of trypanosome histone H3 (TbH3) in a dose dependent manner, with an IC50of 40 nM[1].
Hesperadin (0.01-10 μM; 24 or 48 hours) inhibits growth of bloodstream forms (BF) and procyclic forms (PF) cultures[1].
Hesperadin (100-200 nM; 24-72 hours) alters cell morphology and inhibits cell cycle progression similar to the RNAi knockdown of TbAUK1[1].

Cell Viability Assay[1]

Cell Line:M110 cells
Concentration:0.01, 0.1, 1, 10 μM
Incubation Time:24 hours or 48 hours
Result:Inhibiting growth of BF cultures with an IC50of 50 nM, while the inhibition of PF growth required approximately 11-fold more Hesperadin, with an IC50of 550 nM.

Cell Cycle Analysis[1]

Cell Line:M110 cells
Concentration:100, 200 nM
Incubation Time:24, 48, 72 hours
Result:Had a strong effect on cell growth and mitotic progression at 100-200 nM.
体内研究
(In Vivo)

Hesperadin (20 mg/kg/d; i.v.) prolongs the survival of xenograft mice via synergistic effect with Temozolomide (TMZ)[2].

Animal Model:6-week-old female nude mice injected GBM cells[2]
Dosage:20 mg/kg/d
Administration:I.v. injection
Result:Increased the survival of xenograft mice models.
分子量

553.12

Formula

C29H33ClN4O3S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.