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Aurora A inhibitor 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aurora A inhibitor 2图片
CAS NO:2412144-74-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Aurora A inhibitor 2 (Compound 16h) 是一个有效的Aurora A kinase抑制剂,其IC50值为 21.94 nM。Aurora A inhibitor 2 诱导 MDA-MB-231 细胞 caspase 依赖性凋亡 (apoptosis)。
生物活性

Aurora A inhibitor2 (Compound 16h) is a potentAurora Akinaseinhibitor with anIC50of 21.94 nM.Aurora A inhibitor2 induces caspase-dependentapoptosisin MDA-MB-231 cells[1].

IC50& Target

Aurora A

21.94 nM (IC50)

Aurora B

273.18 nM (IC50)

体外研究
(In Vitro)

Aurora A inhibitor 2 (Compound 16h) (0-20 μM, 48 h) shows potent antiproliferative activity against various human cancer cells, and inhibits colony formation[1].
Aurora A inhibitor 2 (0-4 μM, 24 h) inhibits the expression of phosphorylation of Aurora A and Histone H3 in a dose-dependent manner, and induces G2/M cell cycle arrest[1].
Aurora A inhibitor 2 (0-4 μM, 48 h) induces obvious apoptosis in MDA-MB-231 cells in a concentration-dependent manner[1].

Cell Cytotoxicity Assay[1]

Cell Line:Breast cancer MDA-MB231, prostate cancer PC3, and neuroblastoma SH-SY5Y cells
Concentration:0-20 μM
Incubation Time:48 h
Result:Displayed potent antiproliferative activity with IC50values of 0.38 ± 0.08, 1.09 ± 0.24, and 0.77 ± 0.12 μM against MDA-MB-231, PC3, and SH-SY5Y cells.

Western Blot Analysis[1]

Cell Line:MDAMB-231
Concentration:1, 2, and 4 μM
Incubation Time:24 h
Result:A dose-dependent and significant reduction in the phosphorylation of Aurora A and Histone H3 was observed. Significantly increased the levels of cleaved caspase 3/9 and cleaved-PARP.

Cell Cycle Analysis[1]

Cell Line:MDAMB-231
Concentration:1, 2, and 4 μM
Incubation Time:24 h
Result:Dose-dependently increased the and population of cells in the G2/M phase.

Apoptosis Analysis[1]

Cell Line:MDAMB-231
Concentration:1, 2, and 4 μM
Incubation Time:48 h
Result:Induced obvious apoptosis in a concentration-dependent manner.
分子量

446.50

Formula

C24H26N6O3

CAS 号

2412144-74-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.