CAS NO: | 863598-09-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Casein KinaseII Inhibitor IV is a potent, ATP-competitive ofcasein kinaseIIinhibitor with anIC50of 9 nM.Casein KinaseII Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer[1]. | ||||||||||||||||
IC50& Target | Target: Casein Kinase[1] | ||||||||||||||||
体外研究 (In Vitro) | Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes[1]. | ||||||||||||||||
分子量 | 429.47 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C24H23N5O3 | ||||||||||||||||
CAS 号 | 863598-09-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 33.33 mg/mL(77.61 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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