Orobol

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Orobol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

480-23-9

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

Orobol 是一种主要的大豆异黄酮，具有多种药理活性，包括抗皮肤老化和抗肥胖作用。Orobol 抑制CK1ε、VEGFR2、MAP4K5、MNK1、MUSK、TOPK 和 TNIK (IC₅₀=1.24-4.45 μM)。Orobol 还抑制 PI3K 亚型 (对于 PI3K α/β/γ/K/δ，IC₅₀=3.46-5.27μM)。

生物活性

Orobol is one of the major soyisoflavonesand has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibitsCK1ε, VEGFR2, MAP4K5,MNK1, MUSK,TOPK, and TNIK (IC₅₀=1.24-4.45 μM). Orobol also inhibitsPI3Kisoforms (IC₅₀=3.46-5.27 μM forPI3Kα/β/γ/K/δ)^[1]^[2].

体外研究
(In Vitro)

Orobol binds to CK1ε in an ATP-competitive manner and exerts anti-obesity effects by targeting casein kinase 1 epsilon^[2].
Orobol (5-20 μM) effectively suppresses MDI (isobutylmethylxanthine, dexamethasone and insulin (MDI))-induced phosphorylation of 4E-BP1^[2].

体内研究
(In Vivo)

Orobol attenuates high fat diet-induced weight gain and lipid accumulation without affecting food intake in C57BL/6J mice^[2].

Animal Model:	HFD-induced obesity in C57BL/6J mice^[2]
Dosage:	10 mg/kg
Administration:	Intragastrically; daily for 23 weeks
Result:	Significantly reduced body weight by 17.3% compared to the HFD group.

分子量

286.24

Formula

C₁₅H₁₀O₆

CAS 号

480-23-9

结构分类

Flavonoids
Isoflavones

Phenols
Polyphenols

来源

Plants
Leguminosae
Glycine max(L.) merr

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.