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Ropivacaine hydrochloride monohydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ropivacaine hydrochloride monohydrate图片
CAS NO:132112-35-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
盐酸罗哌卡因一水合物是一种有效的钠通道阻滞剂，通过可逆抑制神经纤维中的钠离子流入来阻断冲动传导。
Cas No.132112-35-7
别名盐酸罗哌卡因一水合物
化学名(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrate;hydrochloride
Canonical SMILESCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl
分子式C17H29ClN2O2
分子量328.88
溶解度≥ 9.8mg/mL in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ropivacaine hydrochloride monohydrate is an effective, long-acting and local anaesthetic [1].

In COS-7 cells, Ropivacaine hydrochloride monohydrate has been reported to inhibit the the SUR2A/Kir6.2 channel currents. The inhibitory effects of Ropivacaine have shown be concentration-dependent and reversible because the channel currents recovered after washout. Furthermore, the IC50 values of Ropivacaine hydrochloride monohydrate are 249±11, 2235±115, 2442±132 and 2375±179μM for SUR2A/Kir6.2, SUR2B/Kir6.1, SUR2B/Kir6.2 and Kir6.2△C36, respectively. Apart from these, Ropivacaine hydrochloride monohydrate has also demonstrated to inhibit sarcolemmal KATP channels in the cardiovascular system by a stereoselective and tissue-specific way[2].

References:
[1] Reiz S1, Haggmark S, Johansson G, Nath S. Cardiotoxicity of ropivacaine--a new amide local anaesthetic agent. Acta Anaesthesiol Scand. 1989 Feb;33(2):93-8.
[2] Kawano T1, Oshita S, Takahashi A, Tsutsumi Y, Tomiyama Y, Kitahata H, Kuroda Y, Nakaya Y. Molecular mechanisms of the inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on sarcolemmal adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Anesthesiology. 2004 Aug;101(2):390-8.