| CAS NO: | 959-24-0 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 200mg | 电议 |
β-adrenergic receptor antagonist
| Cas No. | 959-24-0 |
| 别名 | 盐酸索他洛尔; MJ 1999 |
| 化学名 | N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide;hydrochloride |
| Canonical SMILES | CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl |
| 分子式 | C12H21ClN2O3S |
| 分子量 | 308.82 |
| 溶解度 | ≥ 15.441mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassinm channels with the IC50 value of ~1.2mM in HEK cell lines [1]. As a class III antiarrhythmic drug, Sotalol hydrochloride has been reported to increase the functional refractory period without reducing conduction velocity, using an in vitro experimental rabbit heart model of reentrant tachycardia. In vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing [2].Besides, Sotalol is a β-adrenergic receptor blocker commonly used in rhythm-control treatment of AF (Atrial fibrillation) [3]. References: |
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