CAS NO: | 1604810-84-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | THZ2 is a potent and selectiveCDK7inhibitor with anIC50of 13.9 nM. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | THZ2 selectively targets CDK7 and potently inhibits the growth of triple-negative but not ER/PR+breast cancer cells. THZ2 at low nanomolar doses also efficiently suppresses the clonogenic growth of TNBC cells with IC50of appr 10 nM. THZ2 induces apoptotic cell death in triple-negative but not ER/PR+breast cancer cells or normal human cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | THZ2 (10 mg/Kg) markedly reduces the growth rate of tumors in mice and demonstrates an anti-tumor activity. Compared to vehicle-treated tumors, tumor tissues isolated from mice treated with THZ2 has reduced proliferation and increased apoptosis, as indicated by immunostaining against Ki67 and cleaved Caspase 3 respectively. THZ2 in NOD-SCID mice leads to reduced body weight, suggesting that THZ2 mayt be less well-tolerated in this particular mouse strain[1]. | ||||||||||||||||
分子量 | 566.05 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C31H28ClN7O2 | ||||||||||||||||
CAS 号 | 1604810-84-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 21.67 mg/mL(38.28 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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