CAS NO: | 2651196-69-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | CDK12-IN-4, a pyrazolotriazine, is a potentCDK12 inhibitorwith anIC50of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1]. | |||
IC50& Target[1] |
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体外研究 (In Vitro) | CDK12-IN-4 (Example 172) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=0.626 nM) and has no effect on CAL-120 cells[1]. | |||
分子量 | 426.42 | |||
Formula | C20H20F2N8O | |||
CAS 号 | 2651196-69-7 | |||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |