CAS NO: | 2062200-97-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor ofCdc7, with anIC50of 3.4 nM, and also shows potent effect withIC50s of 215, 42 nM onCK2,PIM1, respectively, and anEC50of 118 nM on pMCM. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | XL413 (BMS-863233) hydrochloride inhibits the cell proliferation (IC50=2685 nM), decreases cell viability (IC50=2142 nM) and elicits the caspase 3/7 activity (EC50=2288 nM) in Colo-205 cells. XL413 hydrochloride also significantly inhibits the anchorage-independent growth of colo-205 in soft agar (IC50=715 nM)[1]. | ||||||||||||||||
体内研究 (In Vivo) | XL413 (BMS-863233; 100 mg/kg, p.o.) hydrochloride shows excellent plasma exposures in mice and possesses good PK properties. XL413 (10, 30, or 100 mg/kg, p.o.) hydrochloride is well tolerated at all the doses, with no significant body weight loss[1]. | ||||||||||||||||
分子量 | 326.18 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C14H13Cl2N3O2 | ||||||||||||||||
CAS 号 | 2062200-97-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 10 mg/mL(30.66 mM;Need ultrasonic) DMSO : 3.4 mg/mL(10.42 mM;Need ultrasonic and warming) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |