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Alogliptin(SYR322)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alogliptin(SYR322)图片
CAS NO:850649-61-5
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
Alogliptin (formerly also known as SYR-322; trade names Nesina; Kazano, Oseni) is a novel, potent, orally bioavailable, and selective inhibitor of DPP-4 (serine protease dipeptidyl peptidase IV) with potential anti-hyperglycemic activity. It inhibits DPP-4 with an IC50 value of 2.6 nM, and exhibits >10,000-fold selectivity for inhibiting DPP-4 over the closely related DPP isoforms such as DPP-8 and DPP-9. It is an anti-diabetic drug marketed in Japan since 2010; and in 2013, the FDA approved the drug in three formulations: as a stand-alone with the brand-name Nesina, combined with metformin using the name Kazano, and when combined with pioglitazone as Oseni. Like other medications for the treatment of Type 2 diabetes, alogliptin does not decrease the risk of heart attack and stroke.
理化性质和储存条件
Molecular Weight (MW)339.39
FormulaC18H21N5O2
CAS No.850649-61-5 (free base);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 68 mg/mL (200.4 mM)
Water: 2 mg/mL (5.89 mM)
Ethanol:<1 mg/mL
Solubility (In vivo)0.5% methylcellulose: 30 mg/mL
SynonymsSYR 322; Alogliptin; SYR-322; SYR322; Brand name: Nesina, Kazano, Oseni

Chemical Name:   (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile

InChi Key:   ZSBOMTDTBDDKMP-OAHLLOKOSA-N

InChi Code:   1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1

SMILES Code:   n1(c(=O)cc(n(c1=O)Cc1c(cccc1)C#N)N1C[C@@H](CCC1)N)C