CAS NO: | 161058-83-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-basedCDKinhibitor withIC50s of 17 μM and 26 μM forCDK2andCDK1. NU2058 has anti-cancer activity. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors. | ||||||||||||||||
分子量 | 247.30 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H17N5O | ||||||||||||||||
CAS 号 | 161058-83-9 | ||||||||||||||||
中文名称 | O6-环甲基己基鸟嘌呤 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 32 mg/mL(129.40 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |