CDK6/9-IN-1

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CDK6/9-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2414373-55-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CDK6/9-IN-1 (compound 66) 是具有口服活性的CDK 6和CDK 9的双抑制剂，其对CDK 6和CDK 9的IC₅₀值分别为 40.5 nM 和 39.5 nM。

生物活性

CDK6/9-IN-1 (compound 66) is an orally active active and dualCDK6andCDK9inhibitor, withIC₅₀values of 40.5 nM and 39.5 nM forCDK6anmdCDK9, respectively^[1].

IC₅₀& Target^[1]

CDK6

40.5 nM (IC₅₀)

CDK9

39.5 nM (IC₅₀)

体外研究
(In Vitro)

CDK6/9-IN-1 (compound 66, 4 or 8 μM in MDA-MB-231 cells) treatment induces G0/G1 cell cycle arrest (71.85% and 77.51%, respectively), when compared with the control (57.65%)^[1].

体内研究
(In Vivo)

CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment^[1].

分子量

452.94

Formula

C₂₂H₂₅ClN₈O

CAS 号

2414373-55-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.