CDK9-IN-14

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CDK9-IN-14

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2650640-17-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

CDK9-IN-14 是一种有效且具有选择性的CDK9抑制剂，IC₅₀为 6.92 nM。CDK9-IN-14 对 MV4;11 细胞和体内肿瘤模型有较强的抑制作用，选择性好，毒性低，副作用少。

生物活性

CDK9-IN-14 is a potent and selectiveCDK9inhibitor withIC₅₀of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells andin vivotumor models, and has a good selectivity and a low toxicity and few side effects^[1].

IC₅₀& Target^[1]

CDK9

6.92 nM (IC₅₀)

体外研究
(In Vitro)

CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC₅₀= 34 nM^[1].

体内研究
(In Vivo)

CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%^[1].

Animal Model:	Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)^[1]
Dosage:	5 mg/kg
Administration:	p.o., qd, for 9 days
Result:	Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.

分子量

419.42

Formula

C₂₁H₂₃F₂N₃O₄

CAS 号

2650640-17-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.