CDK2-IN-12 (compound 10b) is a potentCDK2inhibitor, with anIC₅₀of 11.6 μM. CDK2-IN-12 inhibitshCA(carbonic anhydrase) isoforms I, II, IX and XII, withK_Ivalues of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity^[1].

CDK2-IN-12 (compound 10b) exerts outstanding anti-proliferative activity against leukemia (CCRF-CEM, HL-60TB, K-562 and MOLT-4), non-small cell lung cancer (HOP-92), colon cancer (COLO 205, HCT-116 and SW-620), renal (ACHN) and breast (MDA-MB-468) cell lines with GI% (percentage growth inhibition) ranging from 80 to 100%^[1].
CDK2-IN-12 displays much enhanced growth inhibitory activity, under normoxic and hypoxic conditions, against MDA-MB-468 (IC50 = 1.37 ± 0.07 and 3.03 ± 0.11 μM) than MCF-7 cells (IC50 = 6.80 ± 0.17 and 15.10 ± 0.82 μM)^[1].

447.47

C₂₀H₁₇N₉O₂S

2410402-88-7

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