SHP2/CDK4-IN-1

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SHP2/CDK4-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SHP2/CDK4-IN-1 (compound 10) 是一种口服有效的SHP2和CDK4双抑制剂，IC₅₀分别为 4.3 和 18.2 nM。SHP2/CDK4-IN-1 能有效诱导 G0/G1 阻滞，抑制 TNBC 细胞增殖。SHP2/CDK4-IN-1 在 EMT6 同基因小鼠模型中显示出显著的抗肿瘤作用。SHP2/CDK4-IN-1 可用于三阴性乳腺癌 (TNBC) 的研究。

生物活性

SHP2/CDK4-IN-1 (compound 10) is an orally active and potentSHP2andCDK4dual inhibitor, withIC₅₀values of 4.3 and 18.2 nM, respectively. SHP2/CDK4-IN-1 effectively induces G0/G1 arrest to prevent the proliferation of TNBC cell lines. SHP2/CDK4-IN-1 shows significant antitumor efficacy in the EMT6 syngeneic mouse model. SHP2/CDK4-IN-1 can be used for triple-negative breastcancer(TNBC) research^[1].

IC₅₀& Target

CDK4

18.2 ± 1.3 nM (IC₅₀)

分子量

693.21

Formula

C₃₃H₃₅ClF₂N₁₀OS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.