您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Elliptinium acetate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Elliptinium acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Elliptinium acetate图片
CAS NO:58337-35-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
NSC 264137
Celiptium
产品介绍
Elliptinium acetate (NSC 264137) 是一种 DNA 插层剂,对 L1 210 细胞具有较强的细胞毒性,并且能与 L1210 细胞的核酸共价结合。Elliptinium acetate 可用于癌症,尤其是转移性乳腺癌的研究。
生物活性

Elliptinium acetate (NSC 264137) is a DNA intercalating agent that is highly cytotoxic to L1 210 cells and covalently binds to nucleic acids from L1210 cells. Elliptinium acetate can be used incancerresearch, particularly in metastatic breastcancer[1][2].

IC50& Target

Nucleic acids[1][2].

体外研究
(In Vitro)

Elliptinium (0.35 μM; 1 h) (9-OH-NME3) shows highly stable covalent bonding to nucleic acids of L1210 cells[1].

Cell Viability Assay[1]

Cell Line:L1 210 cells
Concentration:0.35 μM
Incubation Time:1 h
Result:Exhibited highly stable covalent bonding to DNA and RNA.
Showed no reversal of binding as cells went on replicating during a 40-h period.
分子量

336.38

Formula

C20H20N2O3

CAS 号

58337-35-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.