HDAC8-IN-3 (compound P19) 是一种有效的HDAC8抑制剂，其IC50值为 9.3 μM，可产生热稳定性。HDAC8-IN-3 具有细胞毒性并诱导白血病细胞系凋亡。
| 生物活性 | HDAC8-IN-3 (compound P19) is a potentHDAC8inhibitor withIC50value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and inducesapoptosisin leukemic cell lines[1]. |
| IC50& Target[1] | HDAC8 9.3 μM (IC50) | HDAC4 ＞50 μM (IC50) | HDAC1 ＞50 μM (IC50) | HDAC2 41 μM (IC50) | HDAC3 ＞50 μM (IC50) | HDAC5 ＞50 μM (IC50) | HDAC6 17 μM (IC50) | HDAC8 ＞50 μM (IC50) |
|
体外研究
(In Vitro) | HDAC8-IN-3 (compound P19) (5-200 μM, 48 hours; HEK293T cells) has cytotoxicity in leukemic cell lines[1].
HDAC8-IN-3 (compound P19) (50 μM) inhibits glucose transporter 1 (GLUT1)-mediated glucose transport by down-regulating GLUT1 expression (IC50= 28.2 μM)[1].
HDAC8-IN-3 (compound P19) (79.9 μM; 24 hours) can induce apoptotic death in the CEM cell line[1].
Cell Cytotoxicity Assay[1] | Cell Line: | K562, KCL22 and CEM leukemia cells. | | Concentration: | 50 μM | | Incubation Time: | 48 hours | | Result: | Inhibited withIC50values of 79.9, 85.4 and 43.2 μM for CEM, K562 and KCL22 cells, respectively. |
Apoptosis Analysis[1] | Cell Line: | CEM cells | | Concentration: | 79.9 μM | | Incubation Time: | 24 hours | | Result: | The percentage of apoptotic cells was recorded as 60.97%. |
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
m.cnreagent.com