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HDAC-IN-30
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HDAC-IN-30图片
CAS NO:2756809-34-2
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
HDAC-IN-30 是一种新颖的多靶点HDAC抑制剂，靶点主要有HDAC1(IC50=13.4 nM)，HDAC2(IC50=28.0 nM)，HDAC3(IC50=9.18 nM)，HDAC6(IC50=42.7 nM)，HDAC8(IC50=131 nM)。HDAC-IN-30 表现出非常强大的抗肿瘤作用。
生物活性

HDAC-IN-30 is a novel multi-targetHDACinhibitor, includingHDAC1(IC50=13.4 nM),HDAC2(IC50=28.0 nM),HDAC3(IC50=9.18 nM),HDAC6(IC50=42.7 nM),HDAC8(IC50=131 nM). HDAC-IN-30 exhibits potent antitumor efficacy[1].

IC50& Target

HDAC1

13.4 nM (IC50)

HDAC2

28.0 nM (IC50)

HDAC3

9.18 nM (IC50)

HDAC6

42.7 nM (IC50)

HDAC8

131 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-30 (compound 8 h; 0.5, 1, 2 μM; 48 hours) can effectively activate the p53 pathway by promoting the phosphorylation of p53[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours; HepG2 cells) induces cell cycle arrest at the G2 phase in a concentration-dependent manner[1]. HDAC-IN-30 (0, 1, 2.5, 5 mM; 48 hours) possesses prominent anticancer activity in HepG2 cells[1].

Western Blot Analysis[1]

Cell Line:HepG2 cells
Concentration:0.5, 1, 2 μM
Incubation Time:24 hours
Result:Could effectively activate the p53 pathway by promoting the phosphorylation of p53

Cell Cycle Analysis[1]

Cell Line:HepG2 cells
Concentration:0, 1, 2.5, 5 μM
Incubation Time:48 hours
Result:Cells were arrested at the G2 phase in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line:HepG2 cells
Concentration:0, 1, 2.5, 5 μM
Incubation Time:24 hours
Result:Possessed prominent anticancer activity in HepG2 cells.
体内研究
(In Vivo)

HDAC-IN-30 (12, 24 mg/kg; intraperitoneal injection, every two days for 4 weeks) exhibits potent anticancer activity and no side effects even at high dose (24 mg/kg)[1].

Animal Model:HepG2 xenograft mouse model[1]
Dosage:12, 24 mg/kg
Administration:Intraperitoneal injection, every 2 days, 4 weeks
Result:Exhibited potent anticancer activity
分子量

405.45

Formula

C22H23N5O3

CAS 号

2756809-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.