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Mulberrin(Kuwanon C)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Mulberrin(Kuwanon C)图片
CAS NO:62949-79-5
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Mulberrin (Kuwanon C) 是有机阴离子转运多肽 2B1 (OATP2B1) 介导的 3-硫酸雌酮 (E3S) 摄取的强抑制剂，IC50 值为 1.8±1.5 μM。
Cas No.62949-79-5
别名桑黄酮; Kuwanon C
Canonical SMILESC/C(C)=C\CC1=C2C(C(C(C/C=C(C)\C)=C(C3=C(C=C(O)C=C3)O)O2)=O)=C(O)C=C1O
分子式C25H26O6
分子量422.47
溶解度DMSO: 100 mg/mL (236.70 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.

Mulberrin is a flavone with two isopentenyl groups at positions 3 and 8. Mulberrin is a strong inhibitor of OATP2B1 with more than 80% inhibition.Mulberrin also inhibits organic anion-transporting polypeptide (OATP)-mediated uptake of Atorvastatin, Fluvastatin, and Rosuvastatin[1].

[1]. Wen F, et al. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016;54(2):293-302.