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VER-50589
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VER-50589图片
CAS NO:747413-08-7
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
VER-50589 是一种Hsp90抑制剂,IC50值为 21 nM,Kd值为 4.5 nM。
生物活性

VER-50589 is aHsp90inhibitor, with anIC50of 21 nM and aKdof 4.5 nM.

IC50& Target[1]

HSP90

21 nM (IC50)

体外研究
(In Vitro)

VER-50589 is a Hsp90 inhibitor, with an IC50of 21 nM and a Kdof 4.5 nM. VER-50589 inhibits intrinsic ATPase of full-length recombinant yeast Hsp90, with an IC50of 143 ± 23 nM in the presence of 400 μM ATP. VER-50589 shows antiproliferative activities against various human cancer cells, with the lowest GI50of 32.7 ± 0.2 nM for CH1 human ovarian cells, and mean GI50of 78 ± 15 nM. VER-50589 suppressses the proliferation of human umbilical vein endothelial cells (HUVEC) with GI50value of 19 ± 2.4 nM, and shows higher GI50s against nontumorigenic human breast (MCF10a) and prostate (PNT2) epithelial cells. Furthermore, VER-50589 displays no differences in cellular activities of isogenic cell lines, and these activities are independent of NQO1 expression. VER-50589 also causes G1 and G2-M block (115 or 575 nM) and induces cytostasis in HCT116 colon cancer cells. In addition, VER-50589 causes great uptake in HCT116 cells[1].

体内研究
(In Vivo)

VER-50589 (4 mg/kg, i.p.) exerts a complete HSP90 inhibition in the athymic mice bearing well-established OVCAR3 human ovarian ascites tumors. VER-50589 (100 mg/kg, i.p.) shows reduced tumor volume and tumor weights in the HCT116 colon carcinoma xenografts compared to the control mice group[1].

分子量

388.80

性状

Solid

Formula

C19H17ClN2O5

CAS 号

747413-08-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : ≥ 48 mg/mL(123.46 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5720 mL12.8601 mL25.7202 mL
5 mM0.5144 mL2.5720 mL5.1440 mL
10 mM0.2572 mL1.2860 mL2.5720 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。