Sunitinib-d4 (SU 11248-d4) is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor withIC₅₀s of 80 nM and 2 nM forVEGFR2andPDGFRβ, respectively^[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation ofIre1αby inhibiting autophosphorylation and consequent RNase activation^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

402.50

C₂₂H₂₃D₄FN₄O₂

1126721-79-6

舒尼替尼 d4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.