CAS NO: | 2250019-92-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selectiveIRE1αinhibitor that allosterically attenuatesIRE1α RNase activitywith anIC50of 5.9 nM[1]. | ||||||||
IC50& Target | IRE1α[1] | ||||||||
体外研究 (In Vitro) | Kira8 blocks IRE1α oligomerization, and potently inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs. Kira8 more potently reduces IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2[1]. | ||||||||
体内研究 (In Vivo) | MaleIns2+/Akitamice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks[1].
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分子量 | 637.58 | ||||||||
Formula | C31H30Cl2N6O3S | ||||||||
CAS 号 | 2250019-92-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |