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Kira8 Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kira8 Hydrochloride图片
CAS NO:2250019-92-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
AMG-18 Hydrochloride
产品介绍
Kira8 Hydrochloride (AMG-18 Hydrochloride) 是一种单选择性IRE1α抑制剂,可以变构减弱IRE1α RNase活性,IC50为 5.9 nM。
生物活性

Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selectiveIRE1αinhibitor that allosterically attenuatesIRE1α RNase activitywith anIC50of 5.9 nM[1].

IC50& Target

IRE1α[1]
IC50: 5.9 nM (IRE1α RNase)[1]

体外研究
(In Vitro)

Kira8 blocks IRE1α oligomerization, and potently inhibits IRE1α RNase activity against XBP1 and Ins2 RNAs. Kira8 more potently reduces IRE1α-driven apoptosis in INS-1 cells than KIRA6 and also reverses XBP1 splicing promoted by GNF-2[1].

体内研究
(In Vivo)

MaleIns2+/Akitamice are injected i.p. with KIRA8 (50 mg/kg; daily; for 35 days), significant reduction of hyperglycemia become apparent over several weeks[1].
One week treatment of pre-diabetic NODs mice with Kira8 (50 mg/kg; i.p.; once a day) leads to significant reductions in islet XBP1 splicing and TXNIP mRNAs, and preserves Ins1/Ins2, BiP and MANF mRNAs[1].

Animal Model:MaleIns2+/Akitamice[1]
Dosage:50 mg/kg
Administration:Injected i.p.; daily; for 35 days
Result:Significant reduction of hyperglycemia became apparent over several weeks.
分子量

637.58

Formula

C31H30Cl2N6O3S

CAS 号

2250019-92-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.