HSDVHK-NH2

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HSDVHK-NH2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

848644-86-0

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

HSDVHK-NH2 是整合素 αvβ3-玻璃体结合蛋白的互作抑制剂，其IC₅₀值为 1.74 pg/mL (2.414 pM)。

生物活性

HSDVHK-NH2 is an antagonist of theintegrinαvβ3-vitronectininteraction, with anIC₅₀of 1.74 pg/mL (2.414 pM)^[1]^[2].

IC₅₀& Target

αvβ3

2.74 nM (IC₅₀)

体外研究
(In Vitro)

HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group^[1].
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC₅₀value of 25.72 nM^[2].
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression^[3].

Cell Proliferation Assay^[3]

Cell Line:	HUVEC cells.
Concentration:	0.1, 1, 10, and 100 μg/mL.
Incubation Time:	72 h.
Result:	Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.

分子量

720.78

性状

Solid

Formula

C₃₀H₄₈N₁₂O₉

CAS 号

848644-86-0

Sequence Shortening

HSDVHK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 250 mg/mL(346.85 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.3874 mL	6.9369 mL	13.8739 mL
5 mM	0.2775 mL	1.3874 mL	2.7748 mL
10 mM	0.1387 mL	0.6937 mL	1.3874 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (138.74 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。