CAS NO: | 851333-14-7 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | EMD527040 is a potent and highly selectiveαvβ6antagonist with antifibrotic activities. EMD527040 can be used for carcinoma and liver fibrosis research[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | EMD527040 inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins (IC5050)[1].EMD527040 inhibits the attachment of αvβ6 expressing cells (UCLAP3 cells) to fibronectin at IC50of 1.6 μM, as compared to >50 μM for αvβ3 and αvβ5 integrins[1]. | ||||||||||||||||
体内研究 (In Vivo) | EMD527040 (intraperitoneal injection; 20-60 mg/kg; week 2 to 6 after BDL) attenuates bile ductular proliferation and peribiliary collagen deposition by 40-50%, induces downregulation of fibrogenic and upregulation of fibrolytic genes, and improves liver architecture and function. EMD527040 significantly reduced liver and spleen weights by 22% and 50%, respectively in Mdr2(Abcb4)-/-mice[1].
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分子量 | 587.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C29H32Cl2N4O5 | ||||||||||||||||
CAS 号 | 851333-14-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(170.22 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |