CAS NO: | 1378532-99-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | THI0019 is a potentintegrinα4β1 (VLA-4)agonist with anEC50range of 1-2 μM. THI0019 induces stem/progenitor cells adhesion. THI0019 also regulates adhesion mediated byα4β7,α5β1andαLβ2[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | In cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA, THI0019 shows a dose-dependent enhancement in cell binding with an EC50of 1.7 μM. When VCAM-1 is used as the ligand, THI0019 induces an even more pronounced 100-fold increase in Jurkat cell binding, with an EC50of 1.2 μM. THI0019 induces a dose-dependent increase in EPC binding to VCAM-1 (EC50of 3.7 μM). THI0019 facilitates the rolling and spreading of cells on VCAM-1 and the migration of cells toward SDF-1α[1]. | ||||||||||||||||
分子量 | 601.73 | ||||||||||||||||
性状 | Viscous liquid | ||||||||||||||||
Formula | C29H35N3O7S2 | ||||||||||||||||
CAS 号 | 1378532-99-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 240 mg/mL(398.85 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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