Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibitsmicrotubuleformation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds tomicrotubulewith aK_iof 85 nM^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

926.05

Solid

C₄₆H₅₅D₃N₄O₁₄S

1217854-24-4

硫酸长春新碱 ester (硫酸盐)

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)