HA-100 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

141543-63-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HA-100 hydrochloride 是一种有效的蛋白激酶抑制剂，抑制PKG，PKA，PKC和MLC激酶的IC₅₀值分别为 4 μM、8 μM、12 μM 和 240 μM。HA-100 hydrochloride 也用作ROCK抑制剂。

生物活性

HA-100 hydrochloride is a potentprotein kinaseinhibitor, withIC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) andMLC-kinase, respectively. HA-100 hydrochloride also used as aROCKinhibitor^[1]^[2].

IC₅₀& Target^[1]

PKG

4 μM (IC₅₀)

PKA

8 μM (IC₅₀)

PKC

12 μM (IC₅₀)

MLCK

240 μM (IC₅₀)

ROCK

体外研究
(In Vitro)

HA-100 hydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with K_is of 61 and 6.5 μM, respectively^[1].

分子量

313.80

Formula

C₁₃H₁₆ClN₃O₂S

CAS 号

141543-63-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.