Chroman 1 dihydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Chroman 1 dihydrochloride 是一种高效、选择性的ROCK抑制剂，对 ROCK2 (IC₅₀=1 pM) 的作用比 ROCK1 (IC₅₀=52 pM) 更强。Chroman 1 dihydrochloride 对MRCK也有抑制作用，其IC₅₀值为 150 nM。

生物活性

Chroman 1 dihydrochloride is a highly potent and selectiveROCKinhibitor. Chroman 1 dihydrochloride is more potent againstROCK2(IC₅₀=1 pM) thanROCK1(IC₅₀=52 pM). Chroman 1 dihydrochloride also has inhibitory activity againstMRCK, with anIC₅₀of 150 nM^[1]^[2].

IC₅₀& Target^[1]^[2]

ROCK2

1 pM (IC₅₀)

ROCK1

52 pM (IC₅₀)

MRCK

150 nM (IC₅₀)

体外研究
(In Vitro)

Chroman 1 (50 nM, 24 h) inhibits caspase-3/7 activation and reduces apoptosis in human pluripotent stem cells^[1].

Apoptosis Analysis^[1]

Cell Line:	hESCs (human pluripotent stem cells) (WA09)
Concentration:	50 nM
Incubation Time:	0-12 h or 24 h
Result:	Reduced the number of apoptotic cells, reduced caspase-3/7 activation.

Western Blot Analysis^[1]

Cell Line:	hESCs (human pluripotent stem cells) (WA09)
Concentration:	50 nM
Incubation Time:	24 h
Result:	Partially inhibited caspase-3 activation.

分子量

509.43

Formula

C₂₄H₃₀Cl₂N₄O₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.