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WS3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WS3图片
CAS NO:1421227-52-2
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)569.58
FormulaC28H30F3N7O3
CAS No.1421227-52-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (175.6 mM)
Water:<1 mg/mL
Ethanol: 80 mg/mL warmed (140.5 mM)
OtherChemical Name: N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide
InChi Key: KIKOYRNAERIVSJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H30F3N7O3/c1-37-10-12-38(13-11-37)16-19-4-5-21(14-23(19)28(29,30)31)35-27(40)34-20-6-8-22(9-7-20)41-25-15-24(32-17-33-25)36-26(39)18-2-3-18/h4-9,14-15,17-18H,2-3,10-13,16H2,1H3,(H2,34,35,40)(H,32,33,36,39)
SMILES Code: CN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
SynonymsWS-3; WS 3; WS3;
实验参考方法
In Vitro

In vitro activity: WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM. WS3 reversibly induces proliferation of primary fetal and adult human retinal pigment epithelial (RPE) cells.


Cell Assay: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells.

In Vivo
Animal model
Formulation & Dosage
ReferencesChem Senses. 2011 Sep;36(7):649-58.; J Am Chem Soc. 2013 Feb 6;135(5):1669-72; ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
生物活性

Proliferation of fetal human RPE cells grown in the presence of WS3. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
(A–B) WS3-expanded fetal human RPE cells grown in the presence of WS3 and differentiated for five weeks. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.

Restoration of a functional RPE monolayer in RCS rats at P90 following transplantation of rat RPE cells expanded with WS3. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.