包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | MS8511 is a selectiveG9a/GLPcovalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, withIC50values of 100 nM (G9a) and 140 nM (GLP), andKdvalues of 44 nM (G9a) and 46 nM (GLP). MS8511 reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectalcancer, andother diseasesuch as Alzheimer’s disease (AD), sickle cell disease, Prader–Willi syndrome (PWS)[1]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | MS8511 (Compound 8, 0-100 μΜ, 10 min) selectively inhibits G9a and GLP against other PKMTs and PRMTs, with IC50values of 100 nM (G9a) and 140 nM (GLP)[1]. Western Blot Analysis[1]
Cell Viability Assay[1]
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分子量 | 495.66 | ||||||||||||||||
Formula | C28H41N5O3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |