CAS NO: | 882663-88-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | AMG-47a is a potent and orally activelymphocyte-specific protein tyrosine kinase(Lck)inhibitor, with anIC50of 0.2 nM. AMG-47a also inhibitsVEGF2,p38α,Jak3andMLRandIL-2withIC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity[1]. | ||||||||||||||||
IC50& Target | IC50: 0.2 nM (Lck), 1 nM (VEGF2), 3 nM (p38α), 72 nM (Jak3), 30 nM (MLR), 21 nM (IL-2)[1] | ||||||||||||||||
分子量 | 535.56 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C29H28F3N5O2 | ||||||||||||||||
CAS 号 | 882663-88-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 34 mg/mL(63.48 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |