Reticuline shows anti-inflammatory effects throughJAK2/STAT3andNF-κBsignaling pathways. Reticuline inhibits mRNA expressions of TNF-α, andIL-6and reduces the phosphorylation levels ofJAK2andSTAT3^[1]. Reticuline exhibits cardiovascular effects^[2].

Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC₅₀=40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium^[2].
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl₂-induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM)^[2].

Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca²⁺channel blockade and/or 3) inhibition of Ca²⁺release from norepinephrine-sensitive intracellular stores^[2].

329.39

Solid

C₁₉H₂₃NO₄

485-19-8

番荔枝碱；牛心果碱

• Alkaloids
• Isoquinoline Alkaloids

• Phenols
• Polyphenols

• Plants
• Lauraceae
• Lindera aggregata(Sims) Kosterm.

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