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JAK-2/3-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JAK-2/3-IN-1图片
CAS NO:1036241-36-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
JAK-2/3-IN-1 是一种有效的JAK-2JAK-3抑制剂,详细信息请参考专利文献 US8163732B2 中的化合物 46。
生物活性

JAK-2/3-IN-1 is a potentJAK-2andJAK-3inhibitor extracted from patent US8163732B2, compound 46, hasKis of<250 nm for both isoforms[1].

IC50& Target[1]

JAK2

<250 nM (Ki)

JAK3

<250 nM (Ki)

体外研究
(In Vitro)

The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies[1].

分子量

345.78

Formula

C20H12ClN3O

CAS 号

1036241-36-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.