CAS NO: | 1036241-36-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | JAK-2/3-IN-1 is a potentJAK-2andJAK-3inhibitor extracted from patent US8163732B2, compound 46, hasKis of<250 nm for both isoforms[1]. | ||
IC50& Target[1] |
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体外研究 (In Vitro) | The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies[1]. | ||
分子量 | 345.78 | ||
Formula | C20H12ClN3O | ||
CAS 号 | 1036241-36-7 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |