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JAK3-IN-12
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JAK3-IN-12图片
CAS NO:1430095-86-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
JAK3-IN-12 (compound 5k) 是一种高效的JAK3抑制剂,对 JAK3、JAK1 和 JAK2 的IC50为 9.5 nM。JAK3-IN-12 可用于类风湿关节炎的研究。
生物活性

JAK3-IN-12 (compound 5k) is a highly potentJAK3inhibitor withIC50values of 9.5 nM, 18 nM and 42 nM forJAK3,JAK1andJAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].

IC50& Target[1]

JAK3

9.5 nM (IC50)

JAK1

18 nM (IC50)

JAK2

42 nM (IC50)

体内研究
(In Vivo)

JAK3-IN-12 (compound 5k) shows moderate AUC, due to its high clearance, which resulted into overall low bioavailability[1].
Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1].

Tmax(h)Cmax(ng/ml)tmax(h)CL (mL/min/kg), ivAUC0-α(μg/mL·h)F (%)
IV (1 mg/kg);
PO (3 mg/kg)
0.5146±481.85±0.4340.37 ± 3.61192 ± 5615

Animal Model:Male C57BL/6J mice[1]
Dosage:1 mg/kg for IV; 3 mg/kg for PO
Administration:IV or PO; single dosage
Result:Showed moderate AUC, due to its high clearance, which resulted into overall low bioavailability (15%).
分子量

413.45

Formula

C19H19N5O4S

CAS 号

1430095-86-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.