CAS NO: | 2307699-34-7 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Thi-DPPY (compound 8e) is a potent and orally activeJAK3inhibitor withIC50values of 62.4, 1.38 nM forBTK,JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | DPPY (compound 8e) shows anti-proliferative activity against HBE (human bronchial epithelia) cells with an IC50of 39.0 μM[1]. | ||||||||
体内研究 (In Vivo) | DPPY (30, 60 mg/kg; i.g., once daily for 14 days) shows anti-IPF agents on the lung morphology and lung coefficient in mouse model[1].
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分子量 | 566.07 | ||||||||
Formula | C28H28ClN5O4S | ||||||||
CAS 号 | 2307699-34-7 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |