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Thi-DPPY
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thi-DPPY图片
CAS NO:2307699-34-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Thi-DPPY (compound 8e) 是一种有效且具有口服活性的JAK3抑制剂,对 BTK、JAK 的IC50值分别为62.4, 1.38 nM。Thi-DPPY 对 HBE 细胞具有抗增殖活性。Thi-DPPY 在体内显示出抗炎活性。Thi-DPPY 具有研究特发性肺纤维化(IPF)的潜力。
生物活性

Thi-DPPY (compound 8e) is a potent and orally activeJAK3inhibitor withIC50values of 62.4, 1.38 nM forBTK,JAK, respectively. Thi-DPPY shows anti-proliferative activity against HBE cells. Thi-DPPY shows anti-inflammatory activity in vivo. Thi-DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1].

IC50& Target[1]

JAK3

1.38 nM (IC50)

BTK

62.4 nM (IC50)

体外研究
(In Vitro)

DPPY (compound 8e) shows anti-proliferative activity against HBE (human bronchial epithelia) cells with an IC50of 39.0 μM[1].

体内研究
(In Vivo)

DPPY (30, 60 mg/kg; i.g., once daily for 14 days) shows anti-IPF agents on the lung morphology and lung coefficient in mouse model[1].
DPPY (30, 60 mg/kg) significantly decreases the expression of IL-6, IL-17A, TNF-α and MDA in lung tissue in a dose dependent manner[1].

Animal Model:5-6 week old, 20-25 g, C57BL mice (BLM-induced pulmonary inflammation and pulmonary fibrosis model)[1]
Dosage:30, 60 mg/kg
Administration:I.g.; once daily for 14 days
Result:Attenuated the pulmonary morphology changes and reduced the collagen disposition induced by BLM in mouse lung.
分子量

566.07

Formula

C28H28ClN5O4S

CAS 号

2307699-34-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.