JAK1-IN-4 是一种有效、选择性的JAK1抑制剂,对 JAK1,JAK2 和 JAK3 的IC50值分别为 85 nM,12.8 μM 和 >30 μM。在 NCI-H 1975 细胞中,JAK1-IN-4 抑制 STAT3 的磷酸化,IC50值为 227 nM。
生物活性 | JAK1-IN-4 is a potent and selectiveJAK1inhibitor, withIC50s of 85 nM, 12.8 μM and >30 μM forJAK1,JAK2, andJAK3, respectively. JAK1-IN-4 inhibitsSTAT3phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1]. |
IC50& Target[1] | JAK1 85 nM (IC50) | JAK2 12.8 μM (IC50) |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |