CAS NO: | 664993-53-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | JW 55 is a potent and selectiveβ-cateninsignaling pathway inhibitor, which functions via inhibition of thePARPdomain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW 55 decreases auto-PARsylation of TNKS1/2 in vitro withIC50s of 1.9 μM and 830 nM respectively. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | JW 55 (JW55) is a potent and selective inhibitor of the canonical Wnt pathway. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter show inhibition by JW55 with an IC50value of 470 nM. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells. JW55 is effective in the range of 1 to 5 μM in SW480 cells and 0.01 to 5 μM in HCT-15 cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | JW 55 (100 mg/kg, orally) reduces tumor development in conditionalApcknockout mice. JW55 reduces XWnt8-induced axis duplication inXenopusembryos and Tamoxifen-induced polyposis formation in conditional APC mutant mice[1]. | ||||||||||||||||
分子量 | 434.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H26N2O5 | ||||||||||||||||
CAS 号 | 664993-53-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 50 mg/mL(115.08 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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