PF-03622905 is a potent and ATP-competitivePKCinhibitor withIC₅₀s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM forPKCα,PKCβI,PKCβII,PKCγ, andPKCθ, respectively. PF-03622905 shows high specificity forPKCover other protein kinases^[1].

PF-03622905 causes concentration-dependent inhibition of phospho-ERK1/2 formation, interleukin 8 release, and phospho-SHP2 levels with an IC₅₀value 0.15 μM, 0.16 μM, and 35 nM, respectively^[1].
PF-03622905 shows low cytotoxicity at 1 μM against human umbilical vein endothelial cells with remaining cell viability at 83.3% viable^[1].

469.58

C₂₄H₃₅N₇O₃

1072100-15-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.